About Dupixent

Dupixent is an injection that is put under the skin at different injection sites. Dupixent is given in a pre-filled syringe to children ages 6 to 11 based on their weight (100 mg every two weeks or 300 mg every four weeks for children weighing less than 15 kg and 200 mg every two weeks for children weighing more than 30 kg).

It is also available as a 200 mg or 300 mg dose in a pre-filled pen for 12–17-year-olds and adults. Dupixent is meant to be used with the help of a medical professional. It can be given in a clinic or at home by the patient themselves after a medical professional shows them how. Dupixent should only be given at home by a caretaker to children younger than 12 years old.

In the U.S., Dupixent is approved as an add-on maintenance treatment for patients aged 6 years and older with moderate-to-severe asthma with an eosinophilic phenotype or with oral-steroid-dependent asthma; for patients aged 6 years and older with uncontrolled moderate-to-severe atopic dermatitis; and for use with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP)

With the DUPIXENT MyWay® program, Sanofi and Regeneron want to help U.S. patients who are prescribed Dupixent get access to the medicine and get any help they may need. Call 1-844-DUPIXENT (1-844-387-4936) or go to www.DUPIXENT.com for more information.

Dupixent is also approved in Europe, Japan, and other countries around the world for use in certain patients with asthma or CRSwNP in different age groups, as well as in certain patients with moderate-to-severe atopic dermatitis. In more than 60 countries around the world, Dupixent is approved for one or more of these uses, and it has been used to treat more than 300,000 people.

Dupixent is a fully human monoclonal antibody that blocks the signaling of the interleukin-4 (IL-4) and interleukin-13 (IL-13) pathways. It is not an immunosuppressant. The type 2 inflammation that is a big part of atopic dermatitis, asthma, and CRSwNP is mainly caused by IL-4 and IL-13.

Dupilumab Development Program

So far, dupilumab has been studied in more than 10,000 people with chronic diseases that are partly caused by type 2 inflammation in more than 60 clinical trials.

Sanofi and Regeneron are studying dupilumab in a wide range of diseases that are caused by type 2 inflammation or other allergic processes. These diseases include chronic obstructive pulmonary disease with evidence of type 2 inflammation (Phase 3), pediatric atopic dermatitis (6 months to 5 years of age, Phase 3), eosinophilic esophagitis (Phase 3), bullous pemphigoid (Phase 3), prurigo (Phase 2).

At the moment, these possible uses of dupilumab are being tested in clinical trials, and the safety and effectiveness of the drug in these situations have not been fully looked at by any regulatory body. Sanofi and Regeneron are working together to make Dupilumab as part of a global agreement to work together.

The U.S. Food and Drug Administration (FDA) has approved Dupixent® (dupilumab) as an add-on maintenance treatment for patients ages 6 to 11 with moderate-to-severe asthma with an eosinophilic phenotype or oral corticosteroid-dependent asthma.

Naimish Patel, M.D., Head of Global Development in Immunology and Inflammation at Sanofi, says, “This FDA approval gives children with life-threatening asthma attacks and poor lung function, which could affect their ability to breathe into adulthood, new hope.” “Dupixent has made a difference in the lives of many patients and their families. It has been used to treat more than 300,000 people with three diseases that are caused by type 2 inflammation. We now have the chance to give kids as young as 6 who have certain types of moderate-to-severe asthma a safe and effective option.”

Dupixent Approved For Asthma

One of the most common long-term diseases in children is asthma. In the U.S., about 75,000 kids ages 6 to 11 live with the uncontrolled moderate-to-severe form of the disease, and there are many more like them around the world. Even with the standard treatment of inhaled corticosteroids and bronchodilators, these kids may still have serious symptoms like coughing, wheezing, and trouble breathing. They may also need to take a lot of systemic corticosteroids, which come with a lot of risks.

George D. Yancopoulos, M.D., Ph.D., President and Chief Scientific Officer at Regeneron, says, “Even though there are treatments for moderate to severe asthma, it can have a big effect on children’s developing airways, causing sleepless nights, persistent coughing and wheezing, and potentially life-threatening exacerbations that require the use of systemic steroids that can slow growth.” “This approval means that younger children in the U.S. with certain types of moderate-to-severe asthma can now use Dupixent, which is the first treatment of its kind and has been shown to work and be safe. In our most important trial, Dupixent helped kids ages 6 to 11 breathe better, have fewer asthma attacks, and have a better quality of life in terms of their health. We also keep looking at Dupixent in patients with other skin, respiratory, and gastrointestinal conditions where type 2 inflammation may play a role.

The FDA gave its approval based on data from a Phase 3 randomized, double-blind, placebo-controlled trial that looked at how well Dupixent worked and how safe it was in children with uncontrolled moderate-to-severe asthma who were also taking standard asthma treatment. More than 90% of the children who took part in the study had at least one type 2 inflammatory condition at the same time.

Patients who went into the trial with high levels of a certain type of white blood cell (eosinophils [EOS] 300 cells/l; n=259) and added Dupixent (100 mg or 200 mg every two weeks, depending on weight) to standard-of-care:

Compared to placebo, the number of severe asthma attacks dropped by an average of 65% over one year (0.24 events per year for Dupixent vs. 0.67 for placebo).
As measured by percent predicted pre-bronchodilator FEV1, lung function was better after two weeks and stayed that way for up to 52 weeks (FEV1pp).
At 12 weeks, patients who took Dupixent had better lung function than those who took a placebo by 5.32 percentage points.
Improved asthma control at 24 weeks, with 81% of patients reporting a clinically meaningful improvement based on disease symptoms and effects, compared to 64% of placebo patients, as measured by a 0.5 improvement on a 7-point scale.
Children with high fractional exhaled nitric oxide (FeNO 20 ppb), which is a sign of inflammation in the airways and plays a big role in asthma. In this group of kids, the number of severe asthma attacks went down when Dupixent was added to the standard treatment.

The safety results of the trial were mostly the same as what was already known about the safety of Dupixent in people 12 years and older with uncontrolled moderate-to-severe asthma. However, 2.2% of Dupixent patients and 0.7% of placebo patients reported helminth infections. 83% of people who took Dupixent had side effects, while 80% of people who took a placebo did. Injection site reactions (18% Dupixent, 13% placebo), viral upper respiratory tract infections (12% Dupixent, 10% placebo), and eosinophilia (6% Dupixent, 1% placebo) were the most common side effects that happened more often with Dupixent than with placebo.

In the European Union and other places around the world, Dupixent is being looked at by regulators for children ages 6 to 11 with moderate to severe asthma.

Asthma Hints, Pointers, and Methods That Will Make Breathing Easier

After receiving a diagnosis of asthma, you may experience feelings of anxiety about having an asthma attack and feelings of being overwhelmed by the changes that will need to be made in your life. On the other hand, if you are equipped with some helpful strategies for asthma management, you will be able to significantly improve both the quality and conditions of your life. Continue reading for a variety of useful advice on a variety of asthma-related problems.

When you clean your home, you should avoid sweeping the floors. This will cause dust to fly everywhere, and it will be difficult for you to breathe as a result. Instead, you should use a damp mop so that the dirt and dust will adhere to the floor as you clean it. When you clean, try to avoid using aerosols because some people who have asthma are sensitive to the chemicals in these products.

Remove all traces of food and water from your home. Make sure that your food is stored inside the refrigerator. When you let food or water sit out, you let small insects and roaches into the room, both of which can set off allergic reactions in some people. If you have to store food somewhere other than your refrigerator, you might think about acquiring a food pantry or leaving your windows open.

If your children have asthma, make sure that everyone from their babysitter to their teachers at school knows about it. Your children will be able to go about their day in a far better environment if you make the effort to educate other people about how they can lessen the likelihood that your child may have an asthma attack. Do not make the assumption that everyone is familiar with how to care for children who have asthma.

Exercising in a controlled environment might be a useful strategy for managing asthma symptoms. It is a common misconception that people who suffer from asthma are unable to engage in physical activity, but this is not the case. You can avoid the cold air that is known to worsen asthma by performing your exercise indoors rather than outside.

If you or your child suffers from asthma, you should arrange to have your house evaluated at least once every year. It’s possible that you are unaware that parts of your home that are hidden from view are covered with dust or mold. Find a qualified person to examine your home and provide you with an in-depth report on the current state of affairs.

While you are exercising, do these two measures to either prevent a minor attack from occurring or to conquer one that has already started. First, you need to forcefully exhale all of the air that is now in your lungs. Step Two: Form your lips into the shape of a “O,” almost as if you were going to whistle but not quite as narrowly, and then forcibly draw air back into your lungs until you feel like you have enough air to breathe comfortably. Repeat these actions for as long as you feel anxious about having a heart attack while you are exercising. The rhythm that is created by the breathing brings awareness to the act of breathing itself. In addition to this, it will cause you to hyperventilate slightly, which will result in an increased amount of oxygen being pumped into your circulation.

If you know that you have asthma, you should be sure to exercise in a modest manner. Asthma episodes can be triggered by prolonged or very strenuous physical exertion. Some individuals only ever experience attacks when doing these workouts. When you exercise, make sure to breathe in and out through your nose instead of your mouth because taking in chilly air through your mouth may be what sets off your attacks.

It is strongly suggested that you and everyone in your family get vaccinated against the flu every year. If you suffer from asthma, the last thing you need is an infection in your respiratory system. To begin, you should take some basic precautions, including as washing your hands and getting the recommended immunizations at the appropriate times.

You should try to limit the amount of time and frequency that you spend in close proximity to animals in order to ease or prevent asthma attacks. It is possible to have an asthma attack induced by dirt or pet dander just being present in the air, even if you do not have an allergy to the hair or dander of pets. This is a regular occurrence among those who suffer from asthma. If you have pets in the house, you should vacuum more frequently to reduce the amount of air pollution they cause.

It has been demonstrated that you should limit the number of cleaning products you use in your home to no more than four. It is possible that doing so will raise the likelihood of asthma episodes. Make an effort to clean with organic items rather than ones that contain chemicals that can be bothersome.

Even if you haven’t been experiencing any symptoms of asthma recently, it is imperative that you continue to take all of your asthma medicine precisely as prescribed by your doctor. The absence of asthma symptoms does not indicate that the condition has been cured; rather, it indicates that the treatment you are receiving is effective. This includes both the drugs you take to avoid attacks and the rescue inhaler you carry with you.

Take a shower or bath every night before going to bed to rid yourself of any irritants that would otherwise bring on an asthma attack. It is possible that sleeping with allergens still on your skin or hair can not only create an allergic reaction, but will also, over time, make you more sensitive to certain triggers.

Make use of the people in your support network so that they can assist you in managing your asthma. Talk to your loved ones about the things that bring on asthma attacks, and enlist their assistance in helping you make changes to your environment or your routine that will make it easier for you to control your condition. The better your network’s understanding of your disease, the simpler it will be for them to offer their assistance in dealing with it.

In order to keep track of how well your asthma is being controlled, you should use a peak flow meter. These hand-held, pocket-sized instruments evaluate how effectively you are able to exhale air from your lungs. Make consistent use of the meter, and be sure to carefully document your findings. This helps you establish how well your disease is genuinely managed and also helps you identify times of the day when your asthma may be more difficult to control.

Ask your doctor to either offer you with information on asthma or point you in the direction of information about asthma. There is a wealth of information available on the Internet; however, not all of it can be relied upon. The more you learn about asthma, the better you will understand how to manage your condition and locate solutions that will reduce the severity of your symptoms.

Allergic reactions are frequently associated with asthma. People who suffer from allergies are more likely to acquire asthma than those who do not, and allergic reactions themselves can be a trigger for asthma episodes in susceptible individuals. Because of this, it is essential to get an accurate diagnosis of your allergies and, more precisely, to be aware of the allergens that you need to avoid. With this knowledge, you will be able to steer clear of situations that could put you at danger for having an asthma attack.

If you suffer with asthma, it is imperative that you are aware of how to manage the condition. If you have the appropriate suggestions and are aware of how to manage it, dealing with the frustration that comes along with asthma can be easier. Following the guidance presented here should help you have a more comfortable life despite having asthma.