Feeling constantly tired and drained? You’re not alone. Fatigue is one of the most common complaints doctors hear from patients. While there are many potential causes of low energy, from poor sleep habits to underlying health conditions, one solution gaining attention is nicotinamide riboside (NR), also known as Niagen.
Niagen is a form of vitamin B3 shown in studies to increase levels of NAD+ in the body. The coenzyme NAD+ (nicotinamide adenine dinucleotide) is an essential molecule in all living cells that is critical for energy generation and regulates numerous biological functions. NAD+ levels naturally decline with age, contributing to fatigue as we get older.
Here are some of the most exciting ways that Niagen may help boost your energy:

1. Improves Mitochondrial Function
Mitochondria, often called the cell’s powerhouses, play a paramount role in producing the energy molecule ATP. Studies have demonstrated that Niagen benefits this process by enhancing mitochondrial health and efficiency. In fact, in a notable study, Niagen was found to increase ATP production in muscle cells by an impressive 50%! By bolstering your mitochondria and energy production, Niagen offers significant potential to elevate physical and mental vitality.
2. Stimulates Sirtuins
Sirtuins are proteins involved in regulating metabolism, Inflammation, ageing, and longevity. Niagen activates sirtuin enzymes, which have been shown to promote energy generation. In studies on mice, boosting sirtuin activity with Niagen resulted in significant gains in energy, endurance, and exercise performance. Activating sirtuins may also mimic the effects of calorie restriction, improving health.

3. Supports Cellular Repair
When NAD+ levels drop, it impairs your body’s ability to repair damaged cells. This accelerates ageing. By replenishing NAD+, Niagen enhances DNA repair and cellular regeneration. This allows your body to function more effectively, with cells operating optimally. Preventing cell and tissue breakdown can make you feel healthier and more energetic as you age.
4. Reduces Inflammation
Chronic Inflammation causes fatigue and zaps energy over time. The excellent news is that Niagen has potent anti-inflammatory effects on the body. It inhibits the production of inflammatory cytokines while stimulating pathways involved in reducing Inflammation. Lower levels of Inflammation can recharge your vitality and well-being.
5. May Increase Nitric Oxide
Nitric oxide dilates blood vessels to enhance blood flow. Some research indicates that niacin can improve nitric oxide levels, which enhances oxygen and nutrient delivery throughout the body. Better circulation means more energy nourishing your tissues. Early research suggests that Niagen supplementation may boost nitric oxide generation.
6. Improves Metabolic Health
Poor metabolic function drags you down. Niagen has been shown to improve metabolism, including glucose regulation and insulin sensitivity. In one trial, obese participants who took Niagen for 12 weeks shed more body fat while increasing lean muscle mass compared to the placebo group. The metabolic enhancements from Niagen may translate into feeling lighter and more energetic in your body.
7. Enhances Athletic Performance
Want more energy to power through your workouts and daily activities? Adding Niagen could help. In a double-blind, placebo-controlled study, competitive cyclists took Niagen for eight weeks. The Niagen group increased time to exhaustion by 92 seconds compared to 15 seconds in the placebo group. The Niagen cyclists also saw a 5% boost in peak power production. For recreational exercisers and athletes alike, Niagen can supply a performance edge.

8. May Increase Endurance
In addition to more energy, Niagen has been shown to enhance endurance capacity in early research. For example, mice fed Niagen for eight weeks could swim significantly longer before reaching exhaustion than control mice. The effects of Niagen on muscle cell regeneration and mitochondrial function likely translate into improved stamina during physical activity.
9. Promotes Healthy Aging
A drop in NAD+ is believed to be a central driver of the ageing process. By replenishing your NAD+ stores, Niagen may slow or reverse aspects of ageing. This means not just more energy as you age but also continued health. Niagen has been shown to increase longevity in animal studies. Ongoing human trials are investigating anti-aging effects.

10. Synergizes with Exercise
Here is exciting news: combining niacin supplementation with exercise may offer even more significant benefits. A study found that eight weeks of Niagen combined with movement led to better cardiorespiratory fitness and skeletal muscle health versus exercise only. This synergistic effect means your workouts will pay off more when fueled by Niagen.
11. Improves Cognitive Function
Your brain needs abundant energy to stay sharp. Research suggests boosting NAD+ with Niagen enhances brain energetics, neuroplasticity, and cognition in animals. People taking Niagen also report feeling greater mental clarity. Supporting healthy brain ageing may help you feel more focused and motivated.
Wrapping Up
Niagen is an innovative way to boost your NAD+ levels, which declines with age. Research shows exciting potential for Niagen to enhance energy production, metabolic function, inflammation control, and more. While larger-scale human trials are still needed, current evidence indicates supplementing with Niagen has considerable promise for fighting fatigue and optimizing wellbeing. There are also minimal risks, given Niagen’s safety and excellent tolerability.
If you feel your energy needs to catch up, Niagen is worth considering. Always talk with your doctor before starting any new supplement. By giving your cells the crucial NAD+ they need, Niagen can help revive your vitality and zest for life.




